Background:

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Applications:

ELISA, WB, IHC

Name of antibody:

PARP1

Immunogen:

Synthetic peptide of human PARP1

Full name:

poly (ADP-ribose) polymerase 1

Synonyms：

PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1

SwissProt:

P09874

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human breast cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

113 kDa

WB Positive control:

Jurkat and Hela cells

WB Recommended dilution:

500-2000