Background:

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Applications:

WB, IF

Name of antibody:

SNCA (Phospho-Tyr136)

Immunogen:

Synthetic peptide of human SNCA (Phospho-Tyr136)

Full name:

synuclein, alpha (non A4 component of amyloid precursor) (Phospho-Tyr136)

Synonyms：

PD1; NACP; PARK1; PARK4

SwissProt:

P37840

WB Predicted band size:

18 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200