Background:

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Applications:

ELISA, IHC

Name of antibody:

WDFY3

Immunogen:

Fusion protein of human WDFY3

Full name:

WD repeat and FYVE domain containing 3

Synonyms:

ALFY; ZFYVE25

SwissProt:

Q8IZQ1

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human prostate cancer

IHC Recommend dilution:

25-100