Full name:

tumor necrosis factor, alpha-induced protein 8

Synonyms:

NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

Swissprot:

O95379

Gene Accession:

BC007014

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.